Michael Appleton’s side will be looking to get back to winning way after slumping to a 1-0 defeat to Blackburn Rovers in midweek.
They will of course be without Josh Bowler, who departed on deadline day, but new signing Callum Wright is available to feature after sealing a permanent move from Leicester City.
The Seasiders are still without seven first-team players through a combination of injuries and suspension, although the problems are finally beginning to ease.
But how they will line-up at the John Smith’s Stadium? Here’s our prediction?
1. Looking for a reaction
The Seasiders will be looking to get back to winning ways after Wednesday night's disappointment Photo: CameraSport - Alex Dodd
2. GK - Dan Grimshaw
Grimmy produced some stunning saves even in defeat on Wednesday night. Photo: CameraSport - Dave Howarth
3. RB - Jordan Gabriel
Gabriel will want to banish his bad memories of being sent off at Huddersfield last season. Photo: CameraSport - Dave Howarth
4. CB - Marvin Ekpiteta
The skipper remains one of the first names on the team sheet. Photo: CameraSport - Dave Howarth
5. CB - Rhys Williams
The Liverpool loanee faces stiff competition from Jordan Thorniley after a couple of shaky displays. Photo: CameraSport - Dave Howarth
6. LB - Dom Thompson
Thompson has enjoyed a strong start to his Blackpool career. Photo: CameraSport - Dave Howarth