Dominic Ballard and Lee Evans are both doubtful for the fixture after picking up problems in the 2-1 victory over Exeter City at the weekend, while Ollie Norburn is set to spend the next month on the sidelines, alongside Ipswich Town loanee Elkan Baggott.
Even without the injuries, Seasiders boss Steve Bruce has stated he’s keen to make a number of changes to get to know his squad better after taking over the role at Bloomfield Road just under a fortnight ago.
Prior to the 63-year-old’s appointment, Blackpool’s only wins had come in cup competitions, including victories over Burton Albion and Blackburn Rovers to help them progress to this stage.
Here’s our predicted XI and bench to take on the Owls:
13. SUB: James Husband
James Husband scored his third goal of the season at the weekend, as he helped Blackpool to a late winner. Photo: CameraSport - Lee Parker
14. SUB: Dominic Thompson
Dominic Thompson's only outing so far this season came in the EFL Trophy tie against Crewe. Photo: CameraSport - Lee Parker
15. SUB: Alex Lankshear
There could also be room for Alex Lankshear on the bench due to the number of injuries. Photo: CameraSport - Lee Parker
16. SUB: CJ Hamilton
CJ Hamilton opened the scoring for the Seasiders at the weekend, after bagging a brace against Crewe in the game before. Photo: CameraSport - Lee Parker
17. SUB: Ryan Finnigan
Ryan Finnigan is getting closer to making a return following a dead leg, and could be needed due to the injuries to Ollie Norburn and Lee Evans. Photo: CameraSport - Lee Parker
18. SUB: Dom Ballard
Dom Ballard is another player who's touch and go after picking up a knock at the weekend. Photo: CameraSport - Lee Parker