Dominic Ballard and Lee Evans are both doubtful for the fixture after picking up problems in the 2-1 victory over Exeter City at the weekend, while Ollie Norburn is set to spend the next month on the sidelines, alongside Ipswich Town loanee Elkan Baggott.
Even without the injuries, Seasiders boss Steve Bruce has stated he’s keen to make a number of changes to get to know his squad better after taking over the role at Bloomfield Road just under a fortnight ago.
Prior to the 63-year-old’s appointment, Blackpool’s only wins had come in cup competitions, including victories over Burton Albion and Blackburn Rovers to help them progress to this stage.
Here’s our predicted XI and bench to take on the Owls:
19. SUB: Kyle Joseph
Kyle Joseph put in a superb shift against Exeter at the weekend in one of his best displays for the club. Photo: CameraSport - Lee Parker