Dominic Ballard and Lee Evans are both doubtful for the fixture after picking up problems in the 2-1 victory over Exeter City at the weekend, while Ollie Norburn is set to spend the next month on the sidelines, alongside Ipswich Town loanee Elkan Baggott.
Even without the injuries, Seasiders boss Steve Bruce has stated he’s keen to make a number of changes to get to know his squad better after taking over the role at Bloomfield Road just under a fortnight ago.
Prior to the 63-year-old’s appointment, Blackpool’s only wins had come in cup competitions, including victories over Burton Albion and Blackburn Rovers to help them progress to this stage.
Here’s our predicted XI and bench to take on the Owls:
7. Elliot Embleton
Elliot Embleton had a big part to play in the build-up to James Husband's eventual winner against Exeter. Photo: CameraSport - Lee Parker
8. Sonny Carey
Sonny Carey found the back of the net in the 4-1 victory over Crewe Alexandra in the EFL Trophy a fortnight ago. Photo: CameraSport - Lee Parker
9. Hayden Coulson
Hayden Coulson could start on the left side of midfield. Photo: CameraSport - Lee Parker
10. Jordan Rhodes
Jordan Rhodes could've had a couple of goals himself off the bench on Saturday before providing the eventual assist for Husband's winner. Photo: CameraSport - Lee Parker
11. Jake Beesley
Jake Beesley has scored two goals so far this season, with one coming in the last round of the EFL Cup against Blackburn Rovers. Photo: CameraSport - Lee Parker
12. SUB: Harry Tyrer
Harry Tyrer made his League One debut for the Seasiders at the weekend. Photo: CameraSport - Lee Parker