Ian Evatt’s side will be looking to set the tone early on, and head into their League One opener against Wycombe Wanderers with a spring in their step from Blundell Park.
Having missed the majority of pre-season action, Albie Morgan, George Honeyman and Leighton Clarkson should all be back to boost the club’s midfield options.
It remains 50/50 whether Tom Bloxham will be back in time, but Fraser Horsfall, Michael Ihiekwe and Dion Charles are all confirmed out.
Here’s our predicted XI and bench to take on Grimsby:
1. Bailey Peacock-Farrell
Bailey Peacock-Farrell has been Ian Evatt's first choice goalkeeper since his appointment in October. Photo: Gareth Evans
2. Jordan Williams
Jordan Williams formed part of the Seasiders back three in the last weekend's friendly against Port Vale. Photo: Gareth Evans
3. Olly Casey
After missing the start of the pre-season schedule, Olly Casey is ready to fully feature against Grimsby. Photo: Gareth Evans
4. Zac Ashworth
Zac Ashworth has been handed the number three jersey ahead of the new season. Photo: Gareth Evans
5. Josh Bowler
Josh Bowler has been trialled as a wing-back during pre-season. Photo: Gareth Evans
6. Jordan Brown
Jordan Brown is Blackpool's main defensive midfield option. Photo: Gareth Evans