Ian Evatt’s side will be looking to set the tone early on, and head into their League One opener against Wycombe Wanderers with a spring in their step from Blundell Park.
Having missed the majority of pre-season action, Albie Morgan, George Honeyman and Leighton Clarkson should all be back to boost the club’s midfield options.
It remains 50/50 whether Tom Bloxham will be back in time, but Fraser Horsfall, Michael Ihiekwe and Dion Charles are all confirmed out.
Here’s our predicted XI and bench to take on Grimsby:
13. SUB: Andy Lyons
Andy Lyons has been used as a centre back during pre-season. Photo: Gareth Evans
14. SUB: Albie Morgan
Albie Morgan is among three midfield players who could be back from injury this weekend. Photo: Gareth Evans
15. SUB: George Honeyman
George Honeyman endured a stop-start pre-season due to injury, but should be back for Grimsby away. Photo: Gareth Evans
16. SUB: Leighton Clarkson
Leighton Clarkson showed snippets of what he could do following his February move to Blackpool, and will be looking to find some more consistency this time around. Photo: Gareth Evans
17. SUB: CJ Hamilton
CJ Hamilton offers an option for the Seasiders on either wing. Photo: Gareth Evans
18. SUB: Kylian Kouassi
Kylian Kouassi is currently Blackpool's only fit back-up striker, with Tom Bloxham still 50/50 and Dion Charles unavailable this weekend. Photo: Gareth Evans