The first chance of the game fell Karoy Anderson’s way after just one minute, but the midfielder was unable to beat Will Norris as he raced off his line.
A second opportunity for the Charlton Athletic loanee quickly followed, with a second shot towards goal heading just over the crossbar.
Wycombe had moments of their own in the first half, and were gifted their clearest by a Seasiders error.
After catching the visitors playing out from the back, the ball found its way to early substitute Fred Onyedinma - who couldn’t generate enough power on his effort to beat Bailey Peacock-Farrell.
The Seasiders edged their way in front immediately after the restart. Trouble stemmed from the CJ Hamilton cross, with Norris pushing the ball behind after nearly being caught out.
From the resulting corner, a Leighton Clarkson ball into the box took a slight touch off Luke Leahy to break the deadlock.
Hamilton had a chance to double the lead, but couldn’t keep his shot down after cutting inside onto his left foot.
Heading into the final 20 minutes, Blackpool had their numbers reduced, with Hayden Coulson sent off after being booked for a second time.
On the back of this, Wycombe had several chances. Onyedinma came close with a headed attempt, before Niall Huggins saw an attempt saved by Peacock-Farrell.
The Northern Ireland international stepped up with more heroics shortly after, completing an impressive double save with a stop to deny Luke Harris from close-range.
Here’s how the Seasiders performed:

13. SUB: Niall Ennis - 5
Not too many chances came Niall Ennis' way following his introduction, with the striker replaced in the closing staged as the defensive effort was boosted. Photo: Gareth Evans

14. SUB: Ashley Fletcher - 6
Ashley Fletcher was introduced in the second half, but couldn't get involved in too much. Photo: Gareth Evans

15. SUB: Zac Ashworth - 7
Zac Ashworth was introduced to help out with the defensive effort after Coulson's red card. Photo: Gareth Evans

16. Other subs - N/A
Ryan Finnigan and Andy Lyons were both introduced for stoppage time. Photo: Gareth Evans

