The first chance of the game fell Karoy Anderson’s way after just one minute, but the midfielder was unable to beat Will Norris as he raced off his line.
A second opportunity for the Charlton Athletic loanee quickly followed, with a second shot towards goal heading just over the crossbar.
Wycombe had moments of their own in the first half, and were gifted their clearest by a Seasiders error.
After catching the visitors playing out from the back, the ball found its way to early substitute Fred Onyedinma - who couldn’t generate enough power on his effort to beat Bailey Peacock-Farrell.
The Seasiders edged their way in front immediately after the restart. Trouble stemmed from the CJ Hamilton cross, with Norris pushing the ball behind after nearly being caught out.
From the resulting corner, a Leighton Clarkson ball into the box took a slight touch off Luke Leahy to break the deadlock.
Hamilton had a chance to double the lead, but couldn’t keep his shot down after cutting inside onto his left foot.
Heading into the final 20 minutes, Blackpool had their numbers reduced, with Hayden Coulson sent off after being booked for a second time.
On the back of this, Wycombe had several chances. Onyedinma came close with a headed attempt, before Niall Huggins saw an attempt saved by Peacock-Farrell.
The Northern Ireland international stepped up with more heroics shortly after, completing an impressive double save with a stop to deny Luke Harris from close-range.
Here’s how the Seasiders performed:
7. Jordan Brown - 8
Jordan Brown put Olly Casey in trouble while playing out in the first half, but ultimately avoided punishment from Wycombe. On the whole, he provided a decent amount of protection to the defence. Photo: Gareth Evans
8. Karoy Anderson - 8
Karoy Anderson had the first chance of the game in the opening minute, but couldn't provide the finish to beat Will Norris. Beyond that, the Charlton Athletic loanee put in his usual shift in the centre of the park. Photo: Gareth Evans
9. Leighton Clarkson - 7
Leighton Clarkson was on hand with a quality corner to force the Wycombe own goal. Photo: Gareth Evans
10. Hayden Coulson - 5
Hayden Coulson was sent off in the 71st minute after being booked for a second time. Photo: Gareth Evans
11. Tom Bloxham - 6
Tom Bloxham couldn't find the gaps that served him so well in last weekend's victory over Peterborough United. Photo: Gareth Evans
12. Dale Taylor - 5
Dale Taylor was kept quiet up front, with limited involvement for the forward on the back of his brace against Peterborough. Photo: Gareth Evans