The first chance of the game fell Karoy Anderson’s way after just one minute, but the midfielder was unable to beat Will Norris as he raced off his line.
A second opportunity for the Charlton Athletic loanee quickly followed, with a second shot towards goal heading just over the crossbar.
Wycombe had moments of their own in the first half, and were gifted their clearest by a Seasiders error.
After catching the visitors playing out from the back, the ball found its way to early substitute Fred Onyedinma - who couldn’t generate enough power on his effort to beat Bailey Peacock-Farrell.
The Seasiders edged their way in front immediately after the restart. Trouble stemmed from the CJ Hamilton cross, with Norris pushing the ball behind after nearly being caught out.
From the resulting corner, a Leighton Clarkson ball into the box took a slight touch off Luke Leahy to break the deadlock.
Hamilton had a chance to double the lead, but couldn’t keep his shot down after cutting inside onto his left foot.
Heading into the final 20 minutes, Blackpool had their numbers reduced, with Hayden Coulson sent off after being booked for a second time.
On the back of this, Wycombe had several chances. Onyedinma came close with a headed attempt, before Niall Huggins saw an attempt saved by Peacock-Farrell.
The Northern Ireland international stepped up with more heroics shortly after, completing an impressive double save with a stop to deny Luke Harris from close-range.
Here’s how the Seasiders performed:
1. How did the Seasiders perform?
Blackpool took on Wycombe Wanderers at Adams Park. Photo: Gareth Evans
2. Bailey Peacock-Farrell - 8
Bailey Peacock-Farrell was the hero in the second half, with the Northern Ireland international making several impressive saves. Photo: Gareth Evans
3. Reuell Walters - 8
Reuell Walters did well on the whole on the right side of the defence, and did his bit to limit Wycombe. Photo: Gareth Evans
4. Olly Casey - 8
Olly Casey dealt with any aerial tests well, and commanded the back line following the second half sending off. Photo: Gareth Evans
5. James Husband - 8
James Husband also did his bit defensively to hold out the home side. Photo: Gareth Evans
6. CJ Hamilton - 7
It was a pretty quiet afternoon for CJ Hamilton attacking down the right, but he did produce the ball that led to the corner for the opener. Photo: Gareth Evans