Head coach Michael Appleton has admitted he may be forced into making changes to keep his players fresh after a below-par display against West Brom on Tuesday night.
That’s easier said than done though, with options still worryingly light on the ground.
Charlie Patino is a doubt once again, while this game comes too soon for Liam Bridcutt. Keshi Anderson could return to the squad, however, although he’s unlikely to be risked from the start.
With that in mind, here’s how we think the Seasiders could line up against the Hatters...
1. GK - Chris Maxwell
I expect Maxi to keep the number one shirt, unless Appleton wants to spring another surprise. Photo: CameraSport - Andrew Kearns
2. RB - Callum Connolly
Connolly could really do with a rest, but unfortunately Pool don't have the luxury of a back-up right-back. Photo: CameraSport - Andrew Kearns
3. CB - Marvin Ekpiteta
The skipper will have to be at the top of his game to deal with Luton's physical frontline. Photo: CameraSport - Andrew Kearns
4. CB - Rhys Williams
Like Connolly, Jordan Thorniley could also do with a rest. Unlike at right-back, Appleton does have backup in the centre of defence. Photo: CameraSport - Andrew Kearns
5. LB - James Husband
Hubby should continue at left-back, although Dom Thompson is also available should Appleton want to make a change. Photo: CameraSport - David Horton
6. CM - Grant Ward
Is this the game where Ward makes his return? If Charlie Patino doesn't make it, he has every chance. Pool certainly can't be as passive in midfield as they were in midweek. Photo: CameraSport - Dave Howarth