The Seasiders start the group stages with a trip to the Brick Community Stadium to take on Wigan Athletic, with home games against Crewe and Aston Villa U21s coming next month.
Several players remain absent due to injury, while Bailey Peacock-Farrell, Dion Charles (both Northern Ireland), and Karoy Anderson (Jamaica) are all on international duty.
Here’s our predicted XI and bench to take on Wigan:
7. Leighton Clarkson
Leighton Clarkson has scored on his last couple of starts in Tangerine. Photo: Gareth Evans
8. Albie Morgan
Albie Morgan will be looking to keep himself ticking over after struggling with injuries in recent years. Photo: Gareth Evans
9. Ilmari Niskanen
Ilmari Niskanen is set to start as he looks to battle his way back after suffering a shoulder injury at the start of last month. Photo: Gareth Evans
10. Tom Bloxham
Tom Bloxham has been Blackpool's brightest figure so far this season. Photo: Gareth Evans
11. Jerry Yates
Jerry Yates was on hand with an impressive finish on Saturday afternoon for his second goal of the season. Photo: Gareth Evans
12. SUB: Charlie Brier
Young goalkeeper Charlie Brier is set to make the bench this evening. Photo: Gareth Evans