Both the Seasiders and their Wirral opponents have already qualified, with the result of the upcoming contest only set to decide who finishes first and second.
Blackpool are currently one point better off than Rovers, so anything apart from a defeat would secure them a home game in the next round.
On the back of Saturday’s 3-1 victory over Cardiff City, Ian Evatt is set to rotate his side.
Here’s our predicted XI and bench for the game at Prenton Park:
13. SUB: CJ Hamilton
CJ Hamilton could be among a couple of senior figures on the bench. Photo: Gareth Evans
14. SUB: Jordan Brown
Jordan Brown could be someone else included in the matchday squad to fill the bench. Photo: Gareth Evans
15. SUB: Ky-Mani Leliendal
Ky-Mani Leliendal did well in the meeting with Nottingham Forest U21s. Photo: Gareth Evans
16. SUB: Spencer Knight
Spencer Knight has been around the Blackpool first-team squad a number of times this season. Photo: Gareth Evans
17. SUB: Jack Richardson
Jack Richardson has two past senior appearances under his belt for the Seasiders. Photo: Gareth Evans
18. SUB: James Butterworth
James Butterworth has been a frequent scorers for the U18s. Photo: Gareth Evans