If the fixture can beat the freezing conditions and go ahead, then the Seasiders will be looking for a major improvement to their home form.
With only two league wins on the Fylde Coast this season, with the last coming back in September, it is something that has become a major headache for Steve Bruce and his side.
Some of Blackpool’s recent away displays do provide reasons to be optimistic that they can turn things around. Last week a late equaliser from Kyle Joseph secured a 1-1 draw away to high flyers Wycombe Wanderers at Adams Park.
Here’s our predicted XI and bench to take on Cambridge:
13. SUB: Elkan Baggott
Elkan Baggott's loan spell with Blackpool has been hindered by injury so far, but he was able to be named among the substitutes for last week's game away to Wycombe. Photo: CameraSport - Lee Parker
14. SUB: Jordan Gabriel
Jordan Gabriel is among a number of players who have had to settle for minutes off the bench in recent times. Photo: CameraSport - Lee Parker
15. SUB: Ollie Norburn
Ollie Norburn's game time has been severely limited in recent times, and has been been an unused substitute for the majority of the last month. Photo: CameraSport - Richard Martin-Rob
16. SUB: Hayden Coulson
Hayden Coulson was one of the players used as a left winger during the absence of CJ Hamilton. Photo: CameraSport - Lee Parker
17. SUB: Sonny Carey
Sonny Carey didn't look too comfortable as a left winger last week, and could drop down to the bench if Hamilton is ready to return. Photo: CameraSport - Lee Parker
18. SUB: Jordan Rhodes
Start have been limited for Jordan Rhodes this season. Photo: CameraSport - Richard Martin-Rob