If the fixture can beat the freezing conditions and go ahead, then the Seasiders will be looking for a major improvement to their home form.
With only two league wins on the Fylde Coast this season, with the last coming back in September, it is something that has become a major headache for Steve Bruce and his side.
Some of Blackpool’s recent away displays do provide reasons to be optimistic that they can turn things around. Last week a late equaliser from Kyle Joseph secured a 1-1 draw away to high flyers Wycombe Wanderers at Adams Park.
Here’s our predicted XI and bench to take on Cambridge:
7. Lee Evans
Lee Evans' performances have been a bit hit and miss in recent weeks, but there's no doubting just how key he actually is for the Seasiders. Photo: CameraSport - Lee Parker
8. Albie Morgan
Albie Morgan has produced some impressive displays throughout the last month, and has been a bright spark for the Seasiders. Photo: CameraSport - Richard Martin-Rob
9. CJ Hamilton
CJ Hamilton could make his return to the starting XI after featuring off the bench in Blackpool's last two games. Photo: CameraSport - Lee Parker
10. Ashley Fletcher
Ashley Fletcher's fortunes in Tangerine have definitely improved across the last month. Photo: CameraSport - Richard Martin-Rob
11. Kyle Joseph
Kyle Joseph claimed a late equaliser in last week's game away to Wycombe Wanderers. Photo: CameraSport - Lee Parker
12. SUB: Richard O'Donnell
Richard O'Donnell has had to settle for a place on the bench in the last couple of months, with Harry Tyrer preferred in goal. Photo: CameraSport - Richard Martin-Rob