The fixture holds importance for several reasons, including what it could mean for the Seasiders’ League One status beyond this season - along with the six matches beyond that.
Ian Evatt’s side currently sit 21st in the third tier, and will be hoping to use their recent 3-2 victory over Port Vale and 0-0 stalemate away to Cardiff City as a platform to build a survival charge on.
Burton are currently four points above Blackpool, with this weekend’s game having the potential to either drag them back into the mix or give them a massive boost in their own hopes of surviving the drop.
Both Bailey Peacock-Farrell and Karoy Anderson are unavailable for this weekend, with the pair on international duty with Northern Ireland and Jamaica respectively.
Here’s our predicted XI and bench to take on the Brewers:
13. SUB: Hayden Coulson
Hayden Coulson was introduced off the bench in South Wales. Photo: Gareth Evans
14. SUB: Zac Ashworth
Zac Ashworth can offer cover at both centre back and left back. Photo: Gareth Evans
15. SUB: Leighton Clarkson
Leighton Clarkson's minute have been limited in recent weeks. Photo: Gareth Evans
16. SUB: Joel Randall
Joel Randall struggled in Blackpool's last home game against Port Vale. Photo: Gareth Evans
17. SUB: Tom Bloxham
Tom Bloxham came the closest to finding a goal away to Cardiff. Photo: Gareth Evans
18. SUB: Dale Taylor
Dale Taylor could return to contention this weekend after several months on the sidelines through injury. Photo: Gareth Evans