On the back of their 3-2 loss to Stevenage on the opening weekend, further defensive frailties were exposed at St James Park.
The opener came after only four minutes, with Reece Cole finding himself with plenty of time and space in the box to slot a shot past Bailey Peacock-Farrell.
Shortly after, a weak hand from the Birmingham City loanee allowed the home side to add another, with a back post header from Jack Fitzwater finding its way into the back of the net.
Ashley Fletcher was able to pull one back for the Seasiders, but it proved to be nothing more than a consolation due to second half goals from Jayden Wareham and Sonny Cox.
Here’s Blackpool’s ratings from Devon:
13. SUB: Tom Bloxham - 5
None of the substitutes were able to make an impact off the bench, with the game pretty much already gone. Photo: Gareth Evans
14. SUB: Ryan Finnigan - 5
Ryan Finnigan was introduced for the final half an hour of action. Photo: Gareth Evans
15. SUB: Malcolm Ebiowei - 5
Malcolm Ebiowei was handed his Blackpool debut off the bench, and showed snippets of what he could be capable of in Tangerine. Photo: Gareth Evans
16. SUB: CJ Hamilton - 5
CJ Hamilton came on as left back for the latter stages. Photo: Gareth Evans