On the back of their 3-2 loss to Stevenage on the opening weekend, further defensive frailties were exposed at St James Park.
The opener came after only four minutes, with Reece Cole finding himself with plenty of time and space in the box to slot a shot past Bailey Peacock-Farrell.
Shortly after, a weak hand from the Birmingham City loanee allowed the home side to add another, with a back post header from Jack Fitzwater finding its way into the back of the net.
Ashley Fletcher was able to pull one back for the Seasiders, but it proved to be nothing more than a consolation due to second half goals from Jayden Wareham and Sonny Cox.
Here’s Blackpool’s ratings from Devon:
7. George Honeyman - 5
George Honeyman didn't look right on the right side, and just couldn't get himself into the game in that position throughout the opening hour. Photo: Gareth Evans
8. Lee Evans- 4
Lee Evans delivered a cross into a perfect area for Fletcher to bag his goal, but apart from that it was a poor afternoon for the midfielder. Photo: Gareth Evans
9. Jordan Brown - 5
Like the rest of the Blackpool team, it wasn't an afternoon where Jordan Brown was able to stand out. Photo: Gareth Evans
10. Emil Hansson - 5
Emil Hansson wasn't able to make much of an impression on his first start for the Seasiders. Photo: Gareth Evans
11. Ashley Fletcher - 6
After being pretty quiet throughout the opening exchanges, Ashley Fletcher came alive at the right moment to pull a goal back for the Seasiders with a header past Joe Whitworth. The forward didn't do much else, and edges a slightly higher rating than the rest just because of the goal. Photo: Gareth Evans
12. Niall Ennis- 5
Niall Ennis was kept quiet throughout the majority of the game at St James Park. Photo: Gareth Evans