The victim, a man aged in his 20s, was found unconscious with stab wounds to his chest in Springfield Road at 4.25am.
Police remain at the scene and Springfield Road and Dickson Road – between Walker Street and Queen Street – are shut for investigation.
A police spokesman said: “We were called around 4.25am today (Friday, June 10) to a report of a man unconscious on Springfield Road, Blackpool.
“Emergency services attended the scene and found a man, believed to be in his 20s with a suspected stab wound to his chest.
“The man was taken to Blackpool Victoria Hospital for treatment and is currently in a serious but stable condition.
“No arrests have been made.
“An investigation is underway and enquiries ongoing.”
Dickson Road remains cordoned off near Funny Girls and officers are advising motorists to find alternative routes this morning.
You can see video of the scene in our media player above.
Bus services are also affected, with services 3 and 4 currently diverting using Queen Street southbound and Talbot Road northbound.
Detective Chief Insp Lee Wilson, of Blackpool CID, added: “This incident has left a young man very poorly in hospital and I would appeal for anyone who saw anything suspicious in the area around Dickson Road, Springfield Street or General Road this morning or who has any information to come forward and speak to us.
“I have a team of detectives who are working on this investigation and we are following a number of lines of enquiry in order to try and identify the offender.
“I am keen to hear from anyone who may have CCTV or dashcam or any taxi drivers who may have been working in the area overnight.
“In order to allow us to do our work we have had to close some parts of Blackpool this morning and I am aware that this may cause people some disruption.
"I make no apology for this but I am grateful for peoples’ understanding and co-operation.”
Anyone with information can contact police on 101 quoting log 0162 of June 10.