LINE UPS: New boys start for Pool
Flores and Danns, who signed from Wigan and Bury respectively in the final stages of the January transfer window, are two of five changes to Pool's line-up from their 2-0 FA Cup at Blackburn Rovers last week.
Brad Potts returns from injury to take his place in midfield, while defender Kelvin Mellor misses out through suspension after being dismissed against Rovers.
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Hide AdJamille Matt also comes into the forward line to replace Bright Osayi-Samuel and will be partnered by Nathan Delfouneso.
Kyle Vassell remains the only absentee, although he returned to training on Thursday.
Blackpool: Slocombe, McAlister, Aimson, Aldred, Robertson, Taylor, Flores, Danns, Potts, Delfouneso, Matt
Subs: Lyness, Nolan, Daniel, Payne, Osayi-Samuel, Odelusi, Cullen
Colchester: Walker, Brindley, Briggs, Eastman, Kent, Elokobi, Garvan, Lapslie, Slater, Porter, Guthrie
Subs: Brill, Doyley, Vincent-Young, Murray, Pyke, Fosu, Johnstone
Referee: Seb Stockbridge