Fleetwood Town face another cup trip to Hull in Papa John's Trophy
Town finished top of their group, then beat Blackpool on penalties in Tuesday's first knockout round to reach the last 16.
Fleetwood and the Tigers have already met twice this season: Town won October's league encounter 4-1 at Highbury but Hull gained revenge with a 2-0 FA Cup first-round victory on Humberside last month.
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Hide AdThe ties are due to be played in the week starting January 11 and the draw was made by former Fleetwood striker Jon Parkin.
Northern draw: Tranmere Rovers v Leicester City Under-21, Lincoln City v Accrington Stanley, Sunderland v Port Vale, Hull City v Fleetwood Town
Southern draw: Bristol Rovers v AFC Wimbledon, Northampton Town v MK Dons, Oxford United v Cambridge United, Peterborough United v Portsmouth
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