The Seasiders got off to a positive start last week with a hard-earned 1-0 win against Reading courtesy of Callum Connolly’s early strike.
But will Appleton stick with the same team? Or make a few changes?
Here’s how we think Blackpool might line-up at the bet365 Stadium...
1. GK - Dan Grimshaw
The number one shirt is Grimshaw's to keep this season, especially with Chris Maxwell out through injury. Photo: CameraSport - Dave Howarth
2. RB - Callum Connolly
While Jordan Gabriel is making good progress in his recovery from injury, tomorrow's game is likely to come too soon for him. Besides, Connolly was excellent at right-back last week. Photo: CameraSport - Dave Howarth
3. CB - Marvin Ekpiteta
The skipper will need to be on his best form to deal with Stoke's aerial presence, although he'll need to perform better with the ball at his feet. Photo: CameraSport - Dave Howarth
4. CB - Rhys Williams
With Richard Keogh still out through injury, Williams is likely to get the nod ahead of Jordan Thorniley again. Photo: CameraSport - Dave Howarth
5. LB - Dom Thompson
The new recruit will be looking to build on his excellent debut in tangerine. Photo: CameraSport - Dave Howarth
6. CM - Kenny Dougall
After doing well off the bench last week, Dougall could be required to add some solidity at the base of the midfield which will also allow Lewis Fiorini to push further up the pitch. Photo: CameraSport - Dave Howarth