Seven players are likely to miss out, but crucially Jerry Yates and Gary Madine could be fit enough to feature.
Lewis Fiorini, meanwhile, comes back into contention after featuring for the development squad in midweek.
With that in mind, here’s how we think the Seasiders might line up against Vincent Kompany’s men...
7. CM - Callum Connolly
Pool really need Connolly's bite in central midfield with the likes of Trybull, Bridcutt and Stewart all out. Photo: CameraSport - Andrew Kearns
8. CM - Charlie Patino
The Arsenal loanee could return to the fold after being benched against Reading. Photo: CameraSport - Alex Dodd
9. CM - Sonny Carey
Carey has to play at this moment in time as he's one of a very select group of players who are offering a goal threat. Photo: CameraSport - Andrew Kearns
10. RW - Josh Bowler
He was wasteful in front of goal last week but at least he offered an attacking threat. Photo: CameraSport - Andrew Kearns
11. LW - Ian Poveda
It's not often he plays out on the left, so Morgan Rogers and CJ Hamilton could also be in contention. Photo: CameraSport - Andrew Kearns
12. ST - Jerry Yates
Assuming he's fit and match ready, he will start. Otherwise Gary Madine will continue as the number nine. Photo: CameraSport - Dave Howarth