Matt Godden opened the scoring for the visitors, before an own goal from Olly Casey doubled their advantage – in a repeat of a similar second half defensive collapse against Huddersfield Town a fortnight ago.
Substitutes on the hour mark proved key for Steve Bruce’s side, as they fought their way back into the contest.
One of the players introduced was Sammy Silvera, who pulled a goal back in the 72nd minute with a curling effort from distance.
Blackpool continued to apply pressure onto the Charlton defence, until their second presented itself, through new signing and fellow substitute Niall Ennis.
After running clean through on goal, Jake Beesley smashed an effort against the crossbar, with the ball coming to the Stoke City loanee for an easy finish on his debut.
Here’s how the Seasiders performed against the Addicks:
7. Rob Apter- 6
Rob Apter was kept pretty quiet on the whole. Photo: CameraSport - Richard Martin-Roberts
8. Albie Morgan- 7
Albie Morgan provided some good balls into the box for the Seasiders. Photo: CameraSport - Richard Martin-Roberts
9. Sonny Carey- 7
Sonny Carey had the clearest chance of the first half, putting a half-volley over the bar. The midfielder had some bright moments again, but wasn't quite at the same level as Tuesday night against Lincoln. Photo: CameraSport - Richard Martin-Rob
10. CJ Hamilton- 6
It's been a quiet few games for CJ Hamilton since returning from injury, and not much went his way down the left against Charlton. Photo: CameraSport - Richard Martin-Rob
11. Tom Bloxham- 7
There were a couple of bright early moments from Tom Bloxham, but he struggled to open up the Charlton defence beyond that. Photo: CameraSport - Richard Martin-Roberts
12. Ashley Fletcher- 6
It was a pretty quiet afternoon for Ashley Fletcher, with the striker unable to really get involved going forward. Photo: CameraSport - Richard Martin-Rob