Michael Appleton’s side will be looking to claim a second successive victory after getting back to winning ways against Watford last weekend.
As for their opponents, the Blades remain top despite a three-game winless run.
The Seasiders still have a number of injury concerns to consider, although the picture could become a little clearer over the next week or two.
Here’s how we think Blackpool will line up...
1. GK - Chris Maxwell
Maxi has impressed since returning to the side, so the number one jersey is his to lose at this moment in time. Photo: CameraSport - Dave Howarth
2. RB - Callum Connolly
With Jordan Gabriel sidelined until the New Year, there's a lot of pressure on Connolly to remain fit. Photo: CameraSport - Dave Howarth
3. CB - Marvin Ekpiteta
The skipper has looked a lot more settled when partnered with Jordan Thorniley in recent weeks. Photo: CameraSport - Alex Dodd
4. CB - Jordan Thorniley
Even when Rhys Williams returns from injury, Thorniley has done more than enough to keep his place in the side. Photo: CameraSport - Dave Howarth
5. LB - Dom Thompson
After a couple of shaky displays, the left-back was much improved against Watford last time out. Photo: CameraSport - Dave Howarth
6. CM - Kenny Dougall
Now back from suspension, Dougall could slot straight back into the side. Unless Appleton is minded to risk Liam Bridcutt's fitness from the start? Photo: CameraSport - Alex Dodd