The Seasiders could be without eight players through injury or suspension, with Michael Appleton confirming he’s likely to have only 17 senior first-team players available to him.
Pool are especially stretched in defence, where options are limited across the board.
With that in mind, here’s how we think the Seasiders could line up against the struggling Tigers tomorrow night...
. Blackpool's manager Michael Appleton looks on
Photographer Andrew Kearns/CameraSport
The EFL Sky Bet Championship - Sheffield United v Blackpool - Saturday 15th October 2022 - Bramall Lane - Sheffield
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With five out through injury and a further three possibly suspended, Michael Appleton is desperately short on options Photo: CameraSport - Andrew Kearns
. GK - Chris Maxwell
Maxi is guaranteed to keep his place after a heroic display at Bramall Lane. Likely to wear the captain's armband as well in the absence of Marvin Ekpiteta. Photo: CameraSport - Andrew Kearns
. RB - Callum Connolly
The versatile defender/midfielder could have filled in at centre-back had Blackpool had other options to play at right-back. Photo: CameraSport - Andrew Kearns
. CB - Rhys Williams
Appleton has revealed Williams isn't fit enough to play the full 90, but he might have no choice but to start him with Marvin Ekpiteta suspended. Photo: CameraSport - Andrew Kearns
1. GK - Chris Maxwell
Maxi is guaranteed to keep his place after a heroic display at Bramall Lane. Likely to wear the captain's armband as well in the absence of Marvin Ekpiteta. Photo: CameraSport - Andrew Kearns
2. RB - Callum Connolly
The versatile defender/midfielder could have filled in at centre-back had Blackpool had other options to play at right-back. Photo: CameraSport - Andrew Kearns
3. CB - Rhys Williams
Appleton has revealed Williams isn't fit enough to play the full 90, but he might have no choice but to start him with Marvin Ekpiteta suspended. Photo: CameraSport - Andrew Kearns
4. CB - Jordan Thorniley
Jud will need to be on top of his game again if Blackpool are going to pick up the three points. His form has been excellent in recent weeks. Photo: CameraSport - Andrew Kearns
5. LB - Luke Garbutt
With Dom Thompson suspended and James Husband unlikely to be risked from the start, Garbutt should be handed a first appearance of the season. Photo: CameraSport - Dave Howarth
6. CM - Kenny Dougall
Liam Bridcutt is unlikely to be risked twice in quick succession, so Dougall should get the nod in a less advanced role than Saturday. Photo: CameraSport - Andrew Kearns