Following their relegation from the Premier League after just one season, the Seasiders came painfully close to an immediate return to the top flight.
Carlton Cole edged the Hammers in front at Wembley, before Tom Ince levelled the scores at the beginning of the second half.
The winner came in the final moments of the contest, with Ricardo Vaz Tê proving to be the hero for the East London outfit.
This marked the beginning of a slump for Blackpool, as members of the 2010 promotion-winning team went their separate ways, while issues with the then-Oyston ownership increased.
Here’s a look at where the Seasiders squad that lost to West Ham are now:
13. SUB: Craig Cathcart
Craig Cathcart made 117 appearances for Blackpool between 2010 and 2014. The defender called time on his playing career back in 2023, following a very brief stint with Belgium Pro League side K.V. Kortrijk. Photo: Chris Brunskill
14. SUB: Keith Southern
Keith Southern won two promotions and made 370 appearances during his decade in Tangerine, and his now an U18s coach with Everton. Photo: Chris Brunskill
15. SUB: Ludovic Sylvestre
Former Barcelona midfielder Ludovic Sylvestre was with Blackpool between 2010 and 2023. After finishing his playing career with Red Star in France, the 41-year-old has gone on to serve as sporting director for the Ligue 2 club. Photo: Scott Heavey
16. SUB: Nouha Dicko
Nouha Dicko was loaned to Blackpool twice from Wigan Athletic during 2012 and 2013. The striker is currently playing for Al Bataeh in the United Arab Emirates. Photo: Charlie Crowhurst
17. SUB: Roman Bednar
Roman Bednar played 11 times for Blackpool in 2012. Since retiring in 2016, the former Czech Republic international has moved into coaching, and was most recently with FK Motorlet Prague. Photo: Stu Forster
18. Manager: Ian Holloway
Ian Holloway was the man that led Blackpool to the Premier League in 2010, and remained with the club until 2012, before going onto to manage the likes of Crystal Palace and Millwall. The 63-year-old has been in charge of Swindon Town since 2024, and finished 9th in League Two last season. Photo: Richard Heathcote