Bizarrely, it’s the first of three straight games against the sides that have already been relegated to League One.
Here’s how we think the Seasiders might line up...
7. CM - Matty Virtue
Now could be the perfect time to hand Virtue his first start of the season. Photo: CameraSport - Alex Dodd
8. RW - CJ Hamilton
Josh Bowler will be pushing to get back into the side, but CJ's pace could be a huge threat in behind. Photo: CameraSport - Rob Newell
9. LW - Keshi Anderson
Keshi has shown impressive discipline in central midfield, but he's better suited to a more creative role. Photo: CameraSport - Dave Howarth
10. ST - Shayne Lavery
It's unlikely Pool will require two big men in attack against Barnsley, so Lavery could come back in. Photo: CameraSport - Dave Howarth
11. ST - Jake Beesley
Madine or Beesley to start in attack? It's a toss of the coin. Beesley might just edge it for his mobility and movement. Photo: CameraSport - Dave Howarth