As it currently stands, Wigan, Blackpool and Reading are the three sides sat inside the bottom three, but a number of clubs are also in the frame.
Here, we take a look at the bookies’ favourites to drop according to Betway.
1. All to play for
The Seasiders will be hoping they're celebrating come the final day of the campaign Photo: CameraSport - Lee Parker
2. Rotherham United - 20/1
Matt Taylor's side are currently 19th, three points clear of the relegation zone. Photo: CameraSport - Mick Walker
3. QPR - 8/1
Gareth Ainsworth's side sit 18th, four points clear of the bottom three after their surprise win against Burnley. Photo: CameraSport - David Horton
4. Cardiff City - 7/1
Sabri Lamouchi's men are three points clear of the relegation zone with a game in hand to play. Photo: CameraSport - Alex Dodd
5. Huddersfield Town - 2/1
Neil Warnock's Terriers sit just a point above the safety line, albeit with a game in hand still to play. Photo: CameraSport - Dave Howarth
6. Reading - 4/7
The Royals are one point adrift of safety having been docked six points by the EFL. Photo: CameraSport - David Horton