Neil Critchley' s men take on a Cardiff side that are in good form, having won four of their last five league games.
If Pool are to get a result, they'll have to do so with a depleted squad with as many as nine players out through injury.
How will that affect their starting line-up?
1. GK - Dan Grimshaw
The impressive shot stopper will keep his place in between the sticks.
3. CB - Oliver Casey
While the news on Marvin Ekpiteta's injury is positive, the skipper is unlikely to be risked this weekend. If that proves to be the case, it could result in a first league start for Casey.
4. CB - Jordan Thorniley
With Marvin Ekpiteta and Richard Keogh out, Thorniley is virtually assured of a starting role.
5. LB - Dujon Sterling
With three games in a week, there's a chance Sterling could be rested for this one with Reece James picked ahead of him. But we've still gone with Sterling.
6. CM - Callum Connolly
Don't be surprised if Kevin Stewart starts on the bench to keep him fresh for QPR and Reading. The chances of the midfielder starting all three games this week is unlikely.