The Seasiders failed to back up their victory over Huddersfield Town last Saturday on their midweek trip to Mansfield.
It proved to be an underwhelming display in Nottinghamshire, with a Jamie McDonnell brace helping the Stags to a 2-0 win – with set pieces proving problematic once again for Steve Bruce’s side.
Like Blackpool, Plymouth have struggled at the beginning of the new campaign, and are still searching for their first win of the League One season.
The trip to Home Park could see a number of players make a return from injury for the Seasiders, but that won’t include Ashley Fletcher – who is still ruled out with a hamstring problem.
Meanwhile, Niall Ennis remains absent due to suspension following his red card against the Terriers.
Here’s our predicted Blackpool starting XI and bench for this weekend:
1. Bailey Peacock-Farrell
Bailey Peacock-Farrell was on hand with a penalty save for the Seasiders on Tuesday night, before Mansfield claimed their two second half goals. Photo: Gareth Evans
2. Danny Imray
Danny Imray could make his competitive debut for the Seasiders after returning to training this week. Photo: Gareth Evans
3. Michael Ihiekwe
Michael Ihiekwe has struggled at the start of his Blackpool career. Photo: Gareth Evans
4. Olly Casey
Olly Casey was Blackpool's standout player last season, and will be looking to rediscover that form on a consistent basis. Photo: Gareth Evans
5. Hayden Coulson
Hayden Coulson is Steve Bruce's current first-choice option at left back. Photo: Gareth Evans
6. George Honeyman
George Honeyman has been Blackpool's standout performer throughout their difficult start to the season. Photo: Gareth Evans