The Seasiders head into the fixture on the back of their 3-0 victory over Stevenage at Bloomfield Road.
Oxford have enjoyed a strong start to the campaign, and currently sit second in the League One table, with five consecutive wins under their belt.
Here is our predicted Blackpool team for Saturday afternoon:
13. SUB: Richard O'Donnell
Richard O'Donnell remains a solid back up for Grimshaw in goal. In the cup games he's featured in, he's always looked like a solid option if he's ever required. Photo: CameraSport - Andrew Kearns
14. SUB: Callum Connolly
Callum Connolly has been on hand with some big performances for Blackpool this season. He is able to play a number of different positions, which makes him a great option from the bench. Photo: CameraSport - Rob Newell
15. SUB: Marvin Ekpiteta
Marvin Ekpiteta was a regular starter in the early weeks of the season but has been utilised more from the bench in the league throughout the last month. Photo: CameraSport - Dave Howarth
16. SUB: Sonny Carey
Sonny Carey has started the last few games and has put in a couple of solid performances, but would most likely be the player in midfield to make way for any changes. Photo: CameraSport - Dave Howarth
17. SUB: Jensen Weir
Jensen Weir is currently on loan with the Seasiders from Brighton & Hove Albion. He will still be looking to make a big impact during his stay at Bloomfield Road. Photo: CameraSport -
18. SUB: Karamoko Dembele
Karamoko Dembele has certainly built up more fitness in the last few weeks. The attacker came off the bench against Charlton to score a superb goal in Blackpool's last away game. Photo: CameraSport - Dave Howarth