The Seasiders head into the fixture on the back of their sixth defeat of the season and more negative injury.
Niall Ennis has been ruled out for the next eight to 10 weeks with a calf problem after being forced off in the first half of Saturday’s 1-0 loss away to Bradford City at Valley Parade.
The striker joins James Husband, George Honeyman and Scott Banks on Blackpool’s current list of absentees.
There was more positive news on Josh Bowler – who should be available to feature against the club he spent time on loan with during the second half of last season.
Here’s our predicted XI and bench to take on Luton:
13. SUB: Andy Lyons
Recent injuries will mean Andy Lyons is back in the Seasiders matchday squad. Photo: Gareth Evans
14. SUB: Fraser Horsfall
Fraser Horsfall is ready for full match action after his recent 90 minute performance in the cup against Barrow. Photo: Gareth Evans
15. SUB: Hayden Coulson
A breather could prove beneficial for Hayden Coulson. Photo: Gareth Evans
16. SUB: Lee Evans
Lee Evans has lost his place in the starting XI in recent weeks. Photo: Gareth Evans
17. SUB: Emil Hansson
Emil Hansson is yet to do anything to impress since his loan move from Birmingham City. Photo: Gareth Evans
18. SUB: Tom Bloxham
Tom Bloxham could be used as a striker again during Niall Ennis' absence. Photo: Gareth Evans