The Seasiders will be hoping to return to winning ways in League One following their defeat to Northampton Town last time out.
Prior to that they had recorded back-to-back 4-0 wins, and had looked ready to push their way up the table.
Following Tuesday’s midweek EFL Trophy game against Barnsley, there’ll be some good selection dilemmas for Neil Critchley.
Here’s our predicted starting XI and bench:
1. Who will start for the Seasiders?
We've taken a look at who could feature for Blackpool against Carlisle United. Photo: CameraSport - Dave Howarth
2. GK: Dan Grimshaw
Dan Grimshaw is the Seasiders' regular man between the sticks in League One. After dropping out of the team for the EFL Trophy tie against Barnsley, he is expected to return. So far this season, he has kept eight clean sheets. Photo: CameraSport - Lee Parker
3. CB: Matthew Pennington
Matthew Pennington also wasn't involved in the EFL Trophy game against Barnsley, but is expected to return. The summer arrival has been a good addition at Bloomfield Road so far. Photo: CameraSport - Dave Howarth
4. CB: Marvin Ekpiteta
Blackpool's last league outing was a day to forget for a number of players, including Marvin Ekpiteta. After looking shaky against Northampton, the defender was much more commanding in the EFL Trophy tie against the Tykes. He faces tough competition from Olly Casey for his spot, but will probably keep his place this weekend. Photo: CameraSport - Dave Howarth
5. CB: James Husband
James Husband was at fault with a costly mistake in the defeat to Northampton. Moments like that are rare for the defender, who has been superb for the Seasiders on the whole this season. Photo: CameraSport - Dave Howarth
6. RWB: CJ Hamilton
CJ Hamilton will be among those hoping to improve on his display against Northampton. The wing-back had been in good form prior to the defeat at Bloomfield Road and will be hoping to replicate that this weekend. Photo: CameraSport - Dave Howarth