The Seasiders bounced back from their defeat to Stockport County and an underwhelming stalemate against Peterborough United with an impressive 3-0 victory over Barnsley at the weekend.
After missing a number of opportunities during the first half, Sonny Carey made amends with a brace after the break, with his two goals coming either side of a Ashley Fletcher header.
Steve Bruce’s side will be looking to back that performance up, in a fixture that was originally due to take place in January, but was called off due to the cold conditions.
The Blackpool boss admits his team selection will be relatively simple based on the performance from Oakwell.
Here’s our predicted XI and bench to take on Cambridge:
13. SUB: Jordan Gabriel
Jordan Gabriel made a rare start in Blackpool's last home game. Photo: CameraSport - Richard Martin-Rob
14. SUB: James Husband
James Husband has dropped down to the bench for Blackpool's last couple of games. Photo: CameraSport - Alex Dodd
15. SUB: Elkan Baggott
Elkan Baggott was among the players to feature off the bench at the weekend. Photo: CameraSport - Rich Linley
16. SUB: Josh Onomah
Josh Onomah got some minutes under his belt at the weekend. Photo: CameraSport - Rich Linley
17. SUB: Sammy Silvera
Sammy Silvera was a doubt for Saturday due to an ankle injury, but was able to feature off the bench. Photo: CameraSport - Rich Linley
18. SUB: Jake Beesley
Jake Beesley has mainly been limited to substitute appearances this season. Photo: CameraSport - Rich Linley