The Seasiders will be looking to build on the seven points they’ve picked up from their first three games in League One this season.
On the back of Saturday’s 4-0 victory over Peterborough United, Ian Evatt is set to welcome two players back into his matchday squad.
Zac Ashworth is available again after serving a one-match ban, while Ilmari Niskanen and Hayden Coulson could both return after their respective injuries.
Despite this, up five senior players are still set to miss the trip to South Yorkshire, with Fraser Horsfall, Michael Ihiekwe, Jordan Brown, Niall Ennis and Dale Taylor all on the current list of absentees.
Here’s our predicted XI and bench to take on Barnsley:
7. Albie Morgan
Albie Morgan has been building himself up as he puts an injury-hit 12 months behind him. Photo: Gareth Evans
8. George Honeyman
George Honeyman provided a precise cross for Anderson's goal against Peterborough. Photo: Gareth Evans
9. CJ Hamilton
CJ Hamilton has put a shift in at both ends of the pitch in the last few weeks. Photo: Gareth Evans
10. Tom Bloxham
Tom Bloxham put in a man of the match-winning display against Peterborough at the weekend. Photo: Gareth Evans
11. Dion Charles
Dion Charles opened his account for the Seasiders with Saturday afternoon's second goal. Photo: Gareth Evans
12. SUB: Luke Southwood
Luke Southwood joined Blackpool last month as the new back-up goalkeeper. Photo: Gareth Evans