The Seasiders had enjoyed a pretty bright start to the contest, but found themselves burnt on the visitors’ first venture forward.
A corner from Aaron Morley was met by Fred Onyedinma - who flicked a header past Bailey Peacock-Farrell.
Josh Bowler looked like the Seasiders’ best route back into the game with some bright moments down the right throughout the first half.
There was also a decent opportunity for Kylian Kouassi to find an equaliser, with the striker only able to find the gloves of Conor Hazard after charging into the box.
The toughest moment for the Wycombe keeper during the opening 45 minutes was a foot race with Hayden Coulson - who was just unable to get to the ball first to make the most of the inviting break.
Just before half time, the Chairboys almost gifted Blackpool an equaliser, with Hazard failing to keep his eye on a Sam Parker back pass, leaving the ball to dribble just wide of the post.
The Northern Ireland international was a bit more alert from the resulting corner, denying a back post header from Zac Ashworth.
Quick reactions were also on display to push away a Bowler attempt in stoppage time.
With chances not presenting themselves immediately after the restart, Ian Evatt introduced Tom Bloxham and Dion Charles off the bench.
This provided no immediate impact, and it was in fact Wycombe’s Junior Quitirna who had the game’s next couple of chances, with one shot being scuffed into the hands of Peacock-Farrell and another going into the side-netting.
Further subs from Blackpool came in the 73rd minute, with Leighton Clarkson introduced alongside Finley Munroe.
The latter’s impact came quickly, finding himself on the end of a Bloxham ball across the face of goal, before firing into the open target.
Here’s how the Seasiders performed:

1. How did the Seasiders perform?
Blackpool took on Wycombe Wanderers at Bloomfield Road. Photo: Gareth Evans

2. Bailey Peacock-Farrell - 6
Bailey Peacock-Farrell couldn't do too much about the early Wycombe goal, and didn't have too many difficult tasks beyond that. Photo: Gareth Evans

3. Jordan Williams - 8
Jordan Williams enjoyed a positive competitive home debut, and brought some good energy to the right side of the Seasiders back three. Photo: Gareth Evans

4. Olly Casey - 7
Olly Casey is the Seasiders most physical defensive figure at the moment, and probably just needs a bit of support in that department. Photo: Gareth Evans

5. Zac Ashworth - 7
Zac Ashworth will be looking to make the left side of defence his own this season, and produced a strong challenge to deny Silko Thomas in the first half. Photo: Gareth Evans

6. Josh Bowler - 8
Josh Bowler was certainly Blackpool's brightest attacking player, with a number of silky moments down the right. The wing-back caught out the Wycombe defence quite a few times, with some clever runs in-behind. Photo: Gareth Evans