Kieron Bowie had opened the scoring for the visitors in the first half, before Jordan Rhodes pulled the Seasiders level in the 63rd minute.
Not long after the equaliser, Sam Hoskins scored the deciding goal to give Jon Brady’s side all three points.
Dan Grimshaw was called into action after only three minutes, with the Blackpool keeper tipping over a well-struck effort from Marc Leonard following some sloppy play at the back.
The opening goal of the evening came on the half hour mark, as Bowie slotted the ball past Grimshaw to give Northampton the lead.
Ahead of the break, both Owen Dale and Carey hit efforts off target in an attempt to quickly pull Blackpool level.
Clear chances were scarce for both sides at the beginning of the second half, before the Seasiders’ equaliser came just after the hour mark. A cross by Kenny Dougall was met by Rhodes in the box, with the Huddersfield loanee powering a header past Max Thompson.
The scores weren’t level for long, as the visitors edged their way back in front. Hoskins intercepted a weak back pass from James Husband, before taking the ball around Grimshaw to finish into an empty net.
Here’s how the Seasiders performed:
7. Kenny Dougall- 7
Blackpool's midfield couldn't really take control of proceedings at Bloomfield Road. Kenny Dougall was solid enough and produced a good cross for Rhodes' goal. Photo: CameraSport - Dave Howarth
8. Sonny Carey- 5
Nothing really came off for Sonny Carey Just proved to be the type of game were he couldn't influence proceedings. Photo: CameraSport - Dave Howarth
9. Owen Dale- 5
Owen Dale worked hard throughout the game but couldn't really create anything concrete. In the latter stages he missed a golden opportunity with a free header in the box with the keeper scrambling. Photo: CameraSport - Dave Howarth
10. Karamoko Dembele- 6
Karamoko Dembele struggled to have a real impact on the game. The 20-year-old perhaps needed more composure when playing through Jake Beesley for what was a scuffed effort by the striker. He picked up a slight knock in the latter stages and limped off. Photo: CameraSport - Dave Howarth
11. Jordan Rhodes- 7
Jordan Rhodes claimed his 11th goal of the season with a great headed finish, on what was a quiet night on the whole for him. Photo: CameraSport - Dave Howarth
12. Jake Beesley- 6
Jake Beesley worked hard for the Seasiders up front but was unable to continue his scoring run. He wasted a huge opportunity at 0-0, with the 26-year-old scuffing an effort in the box. The striker was replaced just after the hour mark. Photo: CameraSport - Dave Howarth