A Jordan Brown shot from distance was the game’s first real opportunity, with Brad Collins collecting the effort comfortably enough.
This was followed by a couple of other dangerous moments, including an Ashley Fletcher header - which was also dealt with by the Brewers shot stopper.
Following the restart, the first real chance fell to Kyran Lofthouse - who could only produce a tame shot to test Franco Ravizzoli.
The next real chance only came in the 90th minute, as Hamilton clinched the win.
On the break, Leighton Clarkson, slipped the winger through down the right, with his shot beating Collins at the front post.
Here’s how the Seasiders performed:
1. How did the Seasiders perform?
Blackpool took on Burton Albion at Bloomfield Road. Photo: Gareth Evans
2. Franco Ravizzoli - 7
There was nothing too testing for Franco Ravizzoli to deal with, but he did his job when required. Photo: Gareth Evans
3. Olly Casey - 6
Olly Casey had looked solid throughout the first half, but was forced off through injury ahead of the break. Photo: Gareth Evans
4. Fraser Horsfall - 7
Fraser Horsfall looked solid at the centre of the defence, and minimised Burton's threat. Photo: Gareth Evans
5. James Husband - 7
James Husband also executed his defensive duties as you would expect him to. Photo: Gareth Evans
6. Josh Bowler - 6
Josh Bowler showed snippets of brilliance but couldn't come alive for long enough to make something happen. Photo: Gareth Evans