The result at Bloomfield Road was the Seasiders’ first home loss of the season.
Second half goals from Korey Smith, James Collins and Martyn Waghorn helped the Rams on their way to the three points, with a strike from Kenny Dougall proving to be nothing more than a consolation for Neil Critchley’s side.
During the first half, Kane Wilson had a couple of chances to put the visitors ahead.
For the first, he glanced a header wide of the target at the back post, while the second proved to be a more glaring miss.
After taking the ball around Dan Grimshaw, he slotted the ball wide of the post, despite having the majority of the goal to aim for.
Meanwhile, down the other end, Jordan Rhodes had an effort pushed wide of the target by Joe Wildsmith.
Following the restart, Derby put themselves in front.
After shrugging off a challenge from Callum Connolly, Nathaniel Mendez-Laing pulled a ball across the box to Korey Smith- who provided the finish.
The Rams doubled their lead just after the 70-minute mark, with Collins finishing past Grimshaw.
Blackpool quickly closed the gap back to one, courtesy of a 25-yard effort from Dougall.
Heading into the latter stages, Derby sealed the victory, with Waghorn on hand to finish off a quick counter-attacking move.
Here’s how the Seasiders performed:

7. Kenny Dougall- 6
Kenny Dougall pulled the goal back for the Seasiders but it was nothing more than a consolation. Photo: CameraSport - Lee Parker

8. Ollie Norburn- 6
There were some decent contributions from Norburn, but not enough support from the midfield as a whole. Photo: CameraSport - Lee Parker

9. Sonny Carey- 6
Sonny Carey gave the ball away on a couple of occasions when he should've been doing better. Came close to equalising in the second half with a header against the bar. Photo: CameraSport - Lee Parker

10. Karamoko Dembele- 6
Like some of other appearances, there were some good signs from Karamoko Dembele. Photo: CameraSport - Lee Parker

11. Owen Dale- 5
Owen Dale couldn't really provide a spark for the Seasiders down the left side. Photo: CameraSport - Lee Parker

12. Jordan Rhodes- 6
The service wasn't really there for Rhodes, who only had one clear chance on goal. Photo: CameraSport - Lee Parker