Karamoko Dembele impressed on his debut for the club, as goals from Sonny Carey and substitute Kylian Kouassi helped the Seasiders to the win in Cumbria.
Neil Critchley made nine changes from the side that overcame Wigan Athletic at the weekend, with only Callum Connolly and Jensen Weir remaining in the starting 11.
Here are some of the standout stats from the game (courtesy of SofaScore):
7. Assists
Owen Dale and Albie Morgan both provided assists. Photo: CameraSport - Dave Howarth
8. Player shots
Sonny Carey, Matthew Pennington and Kylian Kouassi all had shots on target for the Seasiders. Photo: CameraSport - Dave Howarth
9. Individual passing
Owen Dale completed three key passes for the Tangerines. Photo: CameraSport - Dave Howarth
10. Key performer
From Blackpool's starting line-up, Richard O'Donnell scored a statistical rating of 7.5 from SofaScore. Photo: CameraSport - Dave Howarth