One casualty was released from their vehicle by firefighters before being handed into the care of paramedics.
North West Ambulance confirmed a man was taken to hospital with "minor injuries".
The service 1 bus (Fleetwood to Starr Gate) was diverted via Talbot Road, Dickson Road, and Pleasant Street while emergency services made the scene safe.
"We apologise for any inconvenience caused," a spokesman for Blackpool Transport said.
The road has since been cleared and all diversions have ended.
Fire crews were in attendance for approximately 50 minutes.
North West Ambulance Service has been approached for comment.
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