As well as being one of the driving forces behind the Fisherman's Friend brand, Doreen also supported many good causes and community projects in Fleetwood donating millions of pounds through the years.
Tributes have poured into today following the news. You can read some of the many messages here.
Here are just some of many pictures from our archives over the last 30 years.
Doreen Lofthouse with husband Tony Lofthouse (Left) and son Duncan Lofthouse outside the Fleetwood base in 1990.
Doreen at the unveiling of the welcome home statue in Fleetwood L-R Tony Lofthouse, Doreen Lofthouse, Duncan Lofthouse, Linda Lofthouse, Mayoress of Wyre Sue Jolley and Mayor Leonard Jolley.
Doreen Lofthouse M.B.E unveile's a Plaque at the new Lofthouse Foundation Centre Fleetwood.
MRI Scanner opening ceremony, at Victoria Hospital, Blackpool. Pictured from left, Mr Barry Fothergill (Blackpool Victoria Hospital NHS Trust chairman), Mrs Doreen Lofthouse (Lofthouse Foundation Trustee) and Mr David Gill (Blackpool Victoria Hospital NHS Trust Chief Executive).