Fire crews were called to the Promenade near Tiffany's Hotel at 9.08pm, where the rope rescue team from St Anne’s used a basket stretcher to help lift the man safely to the road above.
He was cared for at the scene by paramedics before being taken to hospital for treatment.
An ambulance spokesman said: "We responded to a patient who had fallen from height. A man in his 40s was taken hospital suffering major trauma related injuries."
A fire service spokesman added: "Two fire engines from Blackpool and Bispham, together with an aerial ladder platform from Blackpool and a rope rescue team from St Annes, attended the rescue of a person on the Promenade in Blackpool.
"The casualty had fallen over a wall on the seafront and was rescued by our rope rescue team from St Anne’s and North West Ambulance Service (NWAS) personnel.
"Crews used a basket stretcher to help recover the patient for treatment. They were at the scene for one and a half hours."
North West Ambulance Service has been approached for an update on the man's condition.
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