TEAM NEWS: Seasiders much changed for trip to Charlton
Williams, who was brought in on a free transfer during the summer, replaces Ryan Allsop who drops down to the bench.
The 35-year-old has made three appearances in cup competitions but has yet to appear for Blackpool in League One this season.
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Hide AdElsewhere, Andy Taylor, Sessi D'Almeida, Danny Philliskirk and Armand Gnanduillet also come into the side.
It means Jay Spearing, Sean Longstaff, Viv Solomon-Otabor and Nathan Delfouneso drop down to the bench.
The raft of changes comes at a time where Gary Bowyer is desperately trying to turn around Blackpool's miserable recent form - which has seen them lose three league games on the spin.
They have also picked up just one win from their last nine games.
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Hide AdCharlton, meanwhile, remain sixth in League One despite losing their last two games.
Charlton: Amos, Dijksteel, Konsa, Sarr, Dasilva, Jackson, Aribo, Marshall, Reeves, Magennis, Best
Subs: Phillips, Lennon, Lapslie, Kashi, Dodoo, Ahearne-Grant, Hackett-Fairchild
Blackpool: Williams, Mellor, Tilt, Robertson, Taylor, Ryan, D'Almeida, Cooke, Daniel, Philliskirk, Gnanduillet
Subs: Allsop, Anderton, Spearing, Longstaff, Delfouneso, Solomon-Otabor, Quigley
Referee: John Busby