Will Aimson comes into the defence as the Seasiders revert to a back three, while Kyle Vassell joins Mark Cullen in attack.
Colin Daniel and Nathan Delfouneso are the two to make way.
Despite taking part in a late fitness test, Jamille Matt misses out as does Jim McAlister.
Blackpool go into the game knowing a win against an already relegated Leyton Orient side will guarantee them a play-off spot.
Blackpool: Slocombe, Mellor, Aimson, Aldred, Robertson, Taylor, Payne, Danns, Potts, Cullen, Vassell
Subs: Lyness, Black, Flores, Osayi-Samuel, Delfouneso, Philliskirk, Gnanduillet
Leyton Orient: Sargeant, Janse, Clark, Pollock, Kennedy, Collins, Ochieng, Alzate, Moncur, Semedo, Abrahams
Subs: Janata, Perkins, Happe, Alderson, Koroma, Dalby, Adeboyejo
Referee: David Webb