Railway workers will be carrying out noisy piling work in the Poulton area from tonight.
Engineers will also be working to lower the tracks at Poulton station, as part of the ongoing electrification programme.
"We will make every effort to keep noise to a minimum and we would like to apologise for any inconvenience caused," Network Rail said.
The piling work will be done from 11.45pm today until 10.15am tomorrow, and between 11.45pm and 6.10am from Monday to Thursday.
The work at Poulton station will also start at 11.45pm today, and is set to end by 6.10am on Monday.
It was scheduled so it could be done while trains are not running.
But residents have already reported being kept awake by the noisy work up and down the line, which is being done as part of the Government's Northern Powerhouse project.
Network Rail is upgrading the line between Blackpool North and Preston, with the 17-mile route set to be fully electrified, which it claimed would pave the way for better trains with more seats.
It said it is also improving the track layout and upgrading signalling equipment to cut down on delays, and improve performance.
Work includes replacing 84 signals, and moving signalling control to the Manchester rail operating centre.
Blackpool North and Kirkham and Wesham stations will be remodelled to 'simplify the current layout of the railway'.