Police closed Dickson Road in Blackpool town centre after a man was seen on the roof of Wilko earlier today.
The street was taped off at the junctions with Talbot Road and Queen Street while officers talked to the man, who was sat on the ledge of the multi-storey car-park above the store.
Buses were diverted as a result of the incident, which unfolded at around 11.30am.
Police said an ambulance was called to the scene, while a specialist negotiator was also on his way.
The man, in his 40s, was escorted down from the rooftop at around 12.20pm. He was taken by ambulance to The Harbour, a mental health hospital in Preston New Road, Marton, for treatment, police added.
The road has since been reopened and buses are now running their usual routes.