Shard Road (A588) was closed in both directions between Mains Lane and Bull Park Lane at approximately 3.05pm on Saturday (June 25).
The collision involved a motorbike and a car, according to eyewitness reports.
A large number of emergency service vehicles attended, including police, ambulance crews and fire engines.
It was expected the road would be closed for a number of hours.
Traffic maps of the area showed traffic was coping well following the closure.