Motorists have reported at least one crash involving three cars eastbound on the M55, close to the junction for Kirkham, police said.
A spokesman for the force said one, believed to be a Ford Focus, hit a central reservation at around 7.50am.
Two others were reported to have left the road and be in a roadside ditch, he added.
An ambulance has been called to the scene.
The accident came as wind, rain, and hail battered the Fylde coast.
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