PICTURES: Images of the destruction caused by Blackpool gas explosion
Emergency services were called to Charles Street at around 5.55pm on Saturday following the blast.
A man and a woman were trapped in the wreckage of the three-storey terraced building, described by police as a guest house but understood to have been privately occupied, with rooms rented out by the owners.
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Hide AdWATCH: Video from the scene of the explosionREAD MORE: Major gas explosion 'obliterated' property while elderly couple were insideREAD MORE: 'I thought it was a bomb': Neighbours tell of shock after major gas explosionIt is understood two people were taken to hospital following the explosion, one with 'major trauma injuries', although emergency services have given conflicting reports.
Residents living in the area were evacuated on Saturday night but were allowed to return home on Sunday morning.
Investigation into the blast are ongoing.